7-OH is 7-hydroxymitragynine, an opioid-like alkaloid from the kratom plant. The 7-OH sold in stores is concentrated or chemically made from kratom extract and sold as tablets, gummies, shots and powders.

7-OH is not legally classed as an opioid, but it acts like one. It binds the same mu-opioid receptor as morphine and heroin, and in lab studies it was about 13 times more potent than morphine.

The compound was first identified in 1994. Concentrated 7-OH products are new, spreading through U.S. gas stations and smoke shops in 2023 and 2024.

Is 7-OH legal in New Jersey?

As of September 2026, 7-OH is not yet federally scheduled. The DEA has announced plans to place concentrated 7-OH in Schedule I, and New Jersey bill S301 would make it Schedule I in the state.

Yes. Regular use causes physical dependence and withdrawal, and many people develop a substance use disorder, meaning compulsive use despite harm.

What are 7-OH withdrawal symptoms?

Muscle aches, sweating, chills, runny nose, nausea, diarrhea, insomnia, restlessness, anxiety, irritability and strong cravings.

How long does 7-OH withdrawal last?

Acute withdrawal usually lasts about 3 to 7 days, peaking on days 1 to 3. Sleep problems, anxiety and cravings can continue for weeks.

When does 7-OH withdrawal start?

Usually 6 to 24 hours after the last dose.

What helps with 7-OH withdrawal?

A doctor's evaluation, medication for opioid withdrawal prescribed by a physician, symptom relief for nausea and sleep, fluids, and a structured outpatient program that starts right away.

Can you overdose on 7-OH?

Yes. 7-OH can slow or stop breathing, especially with alcohol, benzodiazepines or other opioids. Call 911 and give naloxone (Narcan) if you suspect an overdose.

Does naloxone work on 7-OH?

Yes. Because 7-OH acts on the opioid receptor, naloxone can reverse a 7-OH overdose, though more than one dose may be needed.

Does Renova Recovery treat 7-OH addiction?

Yes. Renova Recovery in Brick, NJ treats 7-OH and kratom addiction through PHP, IOP and outpatient programs, with individual counseling, relapse prevention and Vivitrol when appropriate.

7-OH is 7-hydroxymitragynine, an opioid-like alkaloid from the kratom plant. The 7-OH sold in stores is concentrated or chemically made from kratom extract and sold as tablets, gummies, shots and powders.

7-OH is not legally classed as an opioid, but it acts like one. It binds the same mu-opioid receptor as morphine and heroin, and in lab studies it was about 13 times more potent than morphine.

The compound was first identified in 1994. Concentrated 7-OH products are new, spreading through U.S. gas stations and smoke shops in 2023 and 2024.

Is 7-OH legal in New Jersey?

As of September 2026, 7-OH is not yet federally scheduled. The DEA has announced plans to place concentrated 7-OH in Schedule I, and New Jersey bill S301 would make it Schedule I in the state.

Yes. Regular use causes physical dependence and withdrawal, and many people develop a substance use disorder, meaning compulsive use despite harm.

What are 7-OH withdrawal symptoms?

Muscle aches, sweating, chills, runny nose, nausea, diarrhea, insomnia, restlessness, anxiety, irritability and strong cravings.

How long does 7-OH withdrawal last?

Acute withdrawal usually lasts about 3 to 7 days, peaking on days 1 to 3. Sleep problems, anxiety and cravings can continue for weeks.

When does 7-OH withdrawal start?

Usually 6 to 24 hours after the last dose.

What helps with 7-OH withdrawal?

A doctor's evaluation, medication for opioid withdrawal prescribed by a physician, symptom relief for nausea and sleep, fluids, and a structured outpatient program that starts right away.

Can you overdose on 7-OH?

Yes. 7-OH can slow or stop breathing, especially with alcohol, benzodiazepines or other opioids. Call 911 and give naloxone (Narcan) if you suspect an overdose.

Does naloxone work on 7-OH?

Yes. Because 7-OH acts on the opioid receptor, naloxone can reverse a 7-OH overdose, though more than one dose may be needed.

Does Renova Recovery treat 7-OH addiction?

Yes. Renova Recovery in Brick, NJ treats 7-OH and kratom addiction through PHP, IOP and outpatient programs, with individual counseling, relapse prevention and Vivitrol when appropriate.

What are street names for 7-OH?

7-OH is often called 7OH, 7-hydroxy, tabs or shots, and may be labeled as enhanced kratom or kratom extract. A related, stronger compound is sold as pseudo or MP.

What is pseudo kratom?

Pseudo is mitragynine pseudoindoxyl (MP), a compound related to 7-OH and even stronger at the opioid receptor. It became a Schedule I substance on August 26, 2026.

7-OH vapes are sold, but there is almost no safety data on inhaling it. Inhaled or not, it carries the same dependence and overdose risk.

Is 7-OH safe during pregnancy?

No. Babies born to mothers who used kratom regularly have gone through newborn withdrawal. If you're pregnant, talk to your OB before stopping so you can do it safely.

Is 7-OH the same as kratom?

No. Kratom is the plant. 7-OH is one of its alkaloids, making up less than 2 percent of the leaf's alkaloids naturally. 7-OH products concentrate it far beyond natural levels.

Is 7-OH stronger than kratom?

Yes. 7-OH is much stronger at the opioid receptor than mitragynine, kratom's main alkaloid, which is why 7-OH products carry more risk of dependence and overdose.

Does 7-OH show up on a drug test?

Standard 5-panel and 10-panel screens are not designed to detect it, but specialized tests can detect mitragynine and 7-OH, and courts and employers increasingly use them.

What is a safe dose of 7-OH?

There is no established safe dose. Products are unregulated, labels can be inaccurate, and tolerance builds quickly.

Can I quit 7-OH cold turkey?

After heavy daily use, stopping all at once can cause severe withdrawal. Talk to a doctor first so you have a medical plan and support in place.

Does 7-OH cause precipitated withdrawal?

7-OH itself doesn't, but starting buprenorphine (Suboxone) or naltrexone (Vivitrol) while 7-OH is still active can trigger sudden, severe precipitated withdrawal. That's why a prescriber times these medications carefully.

How long after 7-OH can I take Suboxone?

There's no fixed number of hours. Prescribers usually wait until clear withdrawal symptoms have started before the first dose, to avoid precipitated withdrawal. Only start buprenorphine under a prescriber's direction.

Does Renova offer 7-OH detox?

No. Renova is outpatient only. If you need medically managed withdrawal first, we help arrange it and then bring you into our program.

Does insurance cover 7-OH addiction treatment?

Most commercial PPO plans cover outpatient substance use treatment. Renova verifies your benefits on the first call.

Can I keep working during 7-OH treatment?

Often, yes. IOP runs 3 hours a day with morning, afternoon or evening options, and OP meets about 90 minutes, usually in the evening.

How do I help a family member addicted to 7-OH?Title or Question

Learn the signs, keep naloxone at home, talk when they're calm, avoid pushing a cold-turkey quit, and make a confidential first call together.

7-OH Withdrawal Symptoms, Timeline & Treatment NJ

What it is: 7-OH (7-hydroxymitragynine) is an opioid-like compound from the kratom plant, concentrated or chemically made and sold as tablets, gummies, shots and powders.
How strong: It binds the same brain receptors as morphine and heroin. In lab studies it was about 13 times more potent than morphine.
Is it new? The compound was identified in 1994. Concentrated 7-OH products are new, spreading through U.S. gas stations and smoke shops in 2023 and 2024.
Is it legal? Not yet federally scheduled as of September 2026. The DEA has announced plans to make concentrated 7-OH Schedule I, and a New Jersey bill would do the same.
Withdrawal: Starts 6 to 24 hours after the last dose, peaks on days 1 to 3, and the physical symptoms usually ease within a week.
Treatment: Outpatient care (PHP, IOP or OP) with counseling, relapse prevention and a medication review. Heavy daily users may need a medically managed withdrawal first.

7-OH is short for 7-hydroxymitragynine, one of more than 40 alkaloids found in the leaves of kratom (Mitragyna speciosa), a tree native to Southeast Asia. In the natural leaf it is a trace compound. The FDA puts it at less than 2 percent of kratom's total alkaloid content.

The 7-OH sold today is different. Manufacturers take mitragynine, kratom's main alkaloid, and chemically convert it into 7-OH, or they concentrate it far beyond anything found in the leaf. The result is a product that acts much more like a prescription opioid than like the kratom powder or tea people have used for decades.

In your body, 7-OH also shows up on its own: the liver turns some of the mitragynine from ordinary kratom into 7-OH. Researchers now believe that conversion explains much of kratom's pain relief and much of its habit-forming pull.

Renova Recovery treats 7-OH dependence as part of our drug addiction treatment programs for adults across New Jersey.

	Kratom leaf	Concentrated 7-OH products
Main active alkaloid	Mitragynine	7-hydroxymitragynine
7-OH content	Under 2% of alkaloids (FDA)	The main ingredient
How it's made	Dried, ground leaf	Chemically converted or concentrated from kratom extract
Common forms	Powder, capsules, tea	Tablets, gummies, drink shots, sublingual films, powders
Opioid receptor strength	Moderate	Stronger than morphine in lab studies
Main risk	Dependence with regular use	Dependence, overdose, slowed breathing

Name you may see or hear	What it refers to
7-OH, 7OH, 7 OH	The common shorthand for 7-hydroxymitragynine
7-hydroxy, 7-OH-MIT, 7-hydroxymitragynine	The chemical name, often in small print on labels
Tabs, 7-OH tabs	Small pressed tablets, the most common form
Shots	Small liquid vials or bottles of 7-OH
Enhanced kratom, kratom extract, kratom alkaloids	Label terms that can hide a high 7-OH content
Pseudo, MP, mitragynine pseudoindoxyl	A newer, stronger related compound sold alongside 7-OH; Schedule I since August 26, 2026
Legal opioid, gas station opioid	Nicknames used by users and in news coverage
Gas station heroin	Usually means tianeptine, a different drug, but people often mix the two up
Brand names	Sold under brands including 7Tabz, Dopium and Zohm, as reported in news coverage

The compound is not new. The products are. Kratom leaf has been chewed and brewed in Thailand, Malaysia and Indonesia for centuries, mostly by laborers looking for energy and relief from aches. 7-OH itself was first identified in the leaf by researchers in 1994. Within a decade, lab studies showed it was far more powerful at the opioid receptor than morphine.

For most of the 2010s, Americans bought kratom as a powder or capsule, often to manage pain or to get off prescription opioids. Around 2023, sellers began making 7-OH directly and packaging it as small tablets and candy-like products.

By late 2024, forensic labs were finding 7-OH as the main ingredient in products sold as "kratom." Stores that had never carried kratom began stocking it by the register, and the FDA started calling it an emerging opioid threat.

When	What happened
Centuries ago	Kratom leaf chewed and brewed as tea in Southeast Asia
1943	Thailand bans kratom (reversed in 2021)
1994	Researchers first isolate 7-hydroxymitragynine from the kratom leaf
Early 2000s	Lab studies find 7-OH far more potent than morphine at the opioid receptor
2000s–2010s	Kratom powder and capsules spread across the U.S.
2016	DEA announces plans to schedule kratom's alkaloids, then withdraws after public pushback
2023–2024	Concentrated and semi-synthetic 7-OH tablets, gummies and shots hit gas stations and smoke shops
July 2025	FDA recommends scheduling 7-OH and issues warning letters to sellers
2026	DEA moves to make concentrated 7-OH Schedule I; New Jersey bill S301 advances

Legally, 7-OH is not classed as an opioid drug. Chemically and in the body, it behaves like one. 7-OH binds to the mu-opioid receptor, the same receptor targeted by morphine, oxycodone, heroin and fentanyl.

In a well-known lab study on animal tissue, 7-OH was about 13 times more potent than morphine. The DEA's 2026 scheduling notice describes its abuse potential as similar to Schedule I and II opioids.

That is why 7-OH produces opioid effects (pain relief, calm, euphoria), opioid side effects (constipation, sedation) and opioid-style withdrawal. It is also why naloxone (Narcan) can reverse a 7-OH overdose.

Most 7-OH is sold as small pressed tablets, often in blister packs or tins of a few pills, and swallowed or dissolved under the tongue. It also comes as gummies, liquid shots, sublingual strips and loose powder. It is sold at gas stations, vape shops, smoke shops and online, often next to energy drinks, with packaging that looks like a supplement.

Because 7-OH wears off within a few hours, heavy users redose throughout the day and often wake at night in withdrawal. Clinicians at Michigan Medicine have described a patient spending about $300 a day on 7-OH.

People start for different reasons, and many start with good intentions. The pattern that brings them to treatment is the same: the dose that worked stops working, use spreads through the day, and stopping brings on withdrawal.

Why people start	What often happens next
Chronic pain	Relief fades as tolerance builds; more tablets are needed for the same effect
Getting off pills, heroin or fentanyl	7-OH replaces one opioid dependence with another
Anxiety or stress	Calm turns into rebound anxiety between doses
Energy for long work shifts	Use moves from occasional to several times a day
Moving up from kratom powder	Tolerance to kratom drives people to stronger 7-OH
Euphoria or curiosity	Cravings and daily use develop within weeks for many people

Some people do. Alcohol is one of the few substances where stopping suddenly can be medically dangerous rather than just miserable. Severe alcohol withdrawal can cause seizures and delirium tremens, and it needs medical supervision.

Renova does not provide medical detox. We are an outpatient facility, and pretending otherwise would put people at risk. What we do is assess honestly, help arrange detox where it is needed, and hold a place for you to step into PHP, IOP or outpatient afterwards.

Tell us on the first call if any of the following is true. It changes what happens next, and it is not a reason to be turned away.

Users describe 7-OH as a warm, calm, pain-free feeling that comes on within about 30 minutes, similar to a prescription opioid. Short-term side effects look like opioid side effects too. Longer-term, the biggest risks are dependence, withdrawal and overdose, especially when 7-OH is combined with other depressants.

Some of the long-term effects below come from research on heavy kratom use, since 7-OH products are too new for long-term studies. Because 7-OH is far stronger, the risks are unlikely to be smaller.

Short-term effects	Side effects	Long-term risks
Pain relief	Nausea and vomiting	Physical dependence
Calm, relaxed feeling	Constipation	Withdrawal when stopping
Euphoria	Drowsiness, nodding off	Rising tolerance
Reduced anxiety	Heavy sweating, itching	Low mood and anxiety between doses
More energy at low amounts (some users)	Pinpoint pupils	Loss of appetite and weight loss
	Dizziness, dry mouth	Low sex drive and hormone changes
	Headache	Liver injury, including dark urine and yellowing skin (reported with kratom products)
	Slowed breathing at high amounts	Darkening of the skin (reported with heavy kratom use)
		Seizures (reported with high kratom intake)
		Overdose, especially mixed with other depressants

No. The FDA calls 7-OH products a potent opioid and an imminent public health hazard. The DEA's July 2026 scheduling notice reported:

165 poison center exposure cases involving 7-OH in the first seven months of 2025, with about 35 percent leading to serious health problems.

9 deaths in the FDA's adverse event database as of February 2026.

85 overdose cases with 7-OH identified in toxicology since 2019, 55 of them fatal.

Signs of a 7-OH overdose: slow or stopped breathing, blue or gray lips, pinpoint pupils, gurgling or snoring sounds, and not waking up when shaken or called.

What to do: call 911, give naloxone (Narcan) if you have it, and stay with the person. Because 7-OH works on the opioid receptor, naloxone can reverse it, but more than one dose may be needed. New Jersey's Naloxone365 program lets adults get naloxone free and anonymously at participating pharmacies. Our Ocean County addiction resources page lists where.

Combined with	Why it's dangerous
Alcohol	Both slow breathing; blackouts and vomiting while sedated
Benzodiazepines (Xanax, Klonopin, Valium)	The most dangerous pairing for stopped breathing
Other opioids (pills, heroin, fentanyl)	Stacked opioid effect; fentanyl contamination risk
Gabapentin or pregabalin	Increases sedation and breathing risk
Sleep aids and sedating antihistamines	Deeper sedation
Stimulants	Masks sedation until the stimulant wears off

Standard 5-panel and 10-panel urine screens are not designed to detect kratom alkaloids, and 7-OH generally does not trigger a standard opiate screen. Specialized tests can detect mitragynine and 7-OH, and more labs, courts, probation departments and employers now order them. If you are in a court-ordered program or on probation, assume you can be tested for it.

How long does 7-OH stay in your system?

7-OH is short-acting, which is why withdrawal can start within hours. How long it stays detectable hasn't been well studied. Kratom alkaloids are generally detectable in urine for several days after regular use, and longer after heavy daily use.

#	DSM-5 criterion	What it looks like with 7-OH
1	Using more or longer than intended	Planning one tablet and finishing the pack
2	Wanting to cut down but not managing it	Repeated promises to stop on Monday
3	Lots of time spent getting, using or recovering	Planning your day around store runs
4	Cravings	Thinking about the next dose while the last one is still working
5	Falling behind at work, school or home	Missed shifts, late bills, dropped responsibilities
6	Using despite relationship problems	Arguments about money or hiding use from a partner
7	Giving up activities	Skipping the gym, hobbies or family time
8	Using in risky situations	Driving after dosing
9	Using despite health problems	Continuing through constipation, low mood or anxiety
10	Tolerance	Needing more tablets for the same effect
11	Withdrawal	Sweats, aches, restlessness when a dose is late

Criteria met in 12 months	Severity
2–3	Mild
4–5	Moderate
6 or more	Severe

In yourself	In someone you love
Dosing on waking to feel normal	Frequent trips to gas stations or smoke shops
Feeling sick, anxious or restless when late on a dose	Small tins, blister packs or tablets around the house
Using more tablets, more often	Nodding off, pinpoint pupils
Spending money you can't spare	Unexplained spending or borrowing
Hiding how much you use	Mood swings, irritability between doses
Failed attempts to stop	Pulling away from family and old routines

Physical symptoms	Emotional and mental symptoms
Muscle, bone and joint aches	Anxiety and panic
Sweating, chills, goosebumps	Restlessness, can't sit still
Runny nose, watery eyes, yawning	Irritability and anger
Nausea, vomiting, diarrhea, stomach cramps	Low mood, depression
Restless legs, jerking movements	Intense cravings
Insomnia	Trouble concentrating
Fast heart rate, raised blood pressure	Feeling flat, no pleasure (later phase)

The Timeline

7-OH Withdrawal Timeline

Most people follow a similar 7-OH withdrawal timeline after their last dose. Symptoms usually start within a day, peak over days 1 to 3 and ease by the end of the first week. Sleep, mood and cravings can hang on for weeks after that. High daily use, mixing 7-OH with other substances and a history of opioid dependence can make every stage longer and harder.

6–24 HOURS
6–24 Hours: First Signs of 7-OH Withdrawal

7-OH wears off fast, so withdrawal can start within hours of your last dose, often around the time the next one would be due. It usually begins as unease: anxiety, restlessness and a pull toward the next dose that is hard to ignore. The body follows with yawning, a runny nose, watery eyes and goosebumps, and sleep gets difficult that first night. Many people dose again at this point just to make the discomfort stop, which is how the cycle keeps going.

Common symptoms: Anxiety, restlessness, yawning, runny nose, watery eyes, trouble sleeping, cravings
DAYS 1–3
Days 1–3: Peak 7-OH Withdrawal Symptoms

This is the hardest stretch of 7-OH withdrawal. Physical symptoms are at their strongest: deep muscle and bone aches, waves of sweating and chills, nausea, vomiting, diarrhea and stomach cramps. Restless legs and insomnia make it hard to rest, and irritability runs high. Cravings are at their most intense, and so is the risk of using again. Keep drinking fluids. If you can't keep fluids down, have chest pain, or are also coming off alcohol or benzodiazepines, get medical help right away.

Common symptoms: Body aches, sweats and chills, nausea, vomiting, diarrhea, stomach cramps, restless legs, insomnia, irritability, the strongest cravings
DAYS 4–7
Days 4–7: 7-OH Withdrawal Symptoms Start to Ease

Most physical symptoms fade by the end of the first week. The aches loosen, the stomach settles and appetite starts to come back. What tends to stay is fatigue, low mood and broken sleep. Feeling better physically can make it seem like the hard part is over, but the brain is still recalibrating, and this is when many people slip. It is the right moment to start outpatient addiction treatment, while the worst is behind you and the reasons to stop are still fresh.

Common symptoms: Fatigue, low mood, poor sleep, lingering cravings
WEEK 2 ONWARD
Week 2 Onward: Post-Acute 7-OH Withdrawal (PAWS)

Once acute withdrawal ends, many people go through post-acute withdrawal syndrome (PAWS) for weeks to a few months. Sleep stays uneven, anxiety comes and goes, and everyday life can feel flat. Cravings can show up out of nowhere, set off by stress, a bad night or driving past the store where you used to buy. Most relapses happen in this stretch, which is why getting through withdrawal is only the start. Structured therapy, relapse prevention skills and, for some people, Vivitrol medication-assisted treatment once you are opioid-free give you support through it.

Common symptoms: Poor sleep, anxiety, flat mood, low energy, cravings that come and go

Renova Recovery is an outpatient program and does not provide medical detox. If your symptoms need medical supervision, tell us on the first call at (908) 533-9808 and we will talk through your next step.

Helps	Doesn't help or adds risk
A doctor's evaluation before you stop	Stopping cold turkey after heavy daily use
Medication for opioid withdrawal, prescribed by a physician	Switching to kratom powder or tianeptine to cope
Symptom medications for nausea, diarrhea, aches and sleep	Alcohol, benzos or sleep aids to knock yourself out
Fluids, electrolytes and regular small meals	Going it alone with no plan for week 2 onward
A structured outpatient program that starts right away	Waiting for the ban to force you off

	Kratom leaf	7-OH products	Short-acting opioids (pills, heroin)
Typical onset	12–24 hours	6–24 hours	8–24 hours
Peak	Days 1–3	Days 1–3	Days 1–3
Intensity	Mild to moderate	Moderate to severe	Moderate to severe
Acute phase	About 3–7 days	About 3–7 days	About 4–10 days
Post-acute symptoms	Common	Common	Common

Some people try to step down gradually instead of stopping all at once. A taper can soften withdrawal, but self-tapering with 7-OH often fails: product strength varies from pack to pack, cravings override the schedule, and there's no standardized research on taper plans for 7-OH.

If you want to taper, do it with a clinician who knows your full substance use and health history, and have outpatient support lined up before you start. That way you have a plan for the hard days and for what comes after.

Option	What it is	Where it fits
Buprenorphine (Suboxone)	A prescription medication for opioid dependence, used in published 7-OH case reports	Prescribed and timed by a physician; Renova coordinates with outside prescribers
Vivitrol (naltrexone)	A monthly injection that blocks the opioid receptor 7-OH acts on	After withdrawal is complete; given on site at Renova when a physician approves
Non-opioid pain care	Physical therapy, non-opioid medications and pain management	For people who started 7-OH for pain; coordinated with your doctors
Therapy and structure	CBT, relapse prevention and a daily program	For cravings, stress and the habits built around 7-OH
Kratom powder	The plant 7-OH comes from	Not a safe swap: keeps dependence going
Tianeptine, pseudo (MP) or kava stacks	Other gas station products	Not a safe swap: tianeptine and MP carry their own opioid-like risks

Level	Schedule	Often the right fit when
Medically managed withdrawal (arranged with a partner)	Several days of medical care	Heavy daily use, other opioids or benzos, or severe withdrawal before
Partial Hospitalization Program (PHP)	6 hours a day, 5 days a week	You need daily structure right after withdrawal
Intensive Outpatient Program (IOP)	3 hours a day, morning, afternoon or evening	You're stable enough to work or care for family while in treatment
Outpatient Program (OP)	About 90 minutes, usually evenings	You're stepping down or need ongoing support

Renova offers medication-assisted treatment with Vivitrol, a once-monthly injection of naltrexone given on site. Naltrexone blocks the opioid receptor that 7-OH acts on, which can cut cravings and take away the reward if someone uses.

Timing matters. Naltrexone started while 7-OH is still active in the body can trigger sudden, severe withdrawal, so it's only considered after withdrawal is complete and you've been off 7-OH long enough. Our affiliated physician decides whether and when Vivitrol makes sense for you. We do not prescribe Suboxone or methadone, and we coordinate with outside prescribers for clients who take buprenorphine.

Most commercial PPO plans cover outpatient treatment for substance use disorders, including 7-OH and kratom. Renova works out of network with commercial PPO plans, and you can verify your insurance online or on the phone.

You call 908-533-9808. Everything you share is confidential
We check your benefits while you're on the phone and walk through your 7-OH use and health.
We recommend a level of care. If you need medical withdrawal first, we help arrange it.
You start, usually the same day or the next. There's no waitlist.

If getting to Brick is a problem, mention it on the first call. See admissions for the full process, or meet the clinical team you'll work with.

What is 7-OH?
7-OH is 7-hydroxymitragynine, an opioid-like alkaloid from the kratom plant. The 7-OH sold in stores is concentrated or chemically made from kratom extract and sold as tablets, gummies, shots and powders.
Is 7-OH an opioid?
7-OH is not legally classed as an opioid, but it acts like one. It binds the same mu-opioid receptor as morphine and heroin, and in lab studies it was about 13 times more potent than morphine.
Is 7-OH a new drug?
The compound was first identified in 1994. Concentrated 7-OH products are new, spreading through U.S. gas stations and smoke shops in 2023 and 2024.
Is 7-OH legal in New Jersey?
As of September 2026, 7-OH is not yet federally scheduled. The DEA has announced plans to place concentrated 7-OH in Schedule I, and New Jersey bill S301 would make it Schedule I in the state.
Is 7-OH addictive?
Yes. Regular use causes physical dependence and withdrawal, and many people develop a substance use disorder, meaning compulsive use despite harm.
What are 7-OH withdrawal symptoms?
Muscle aches, sweating, chills, runny nose, nausea, diarrhea, insomnia, restlessness, anxiety, irritability and strong cravings.
How long does 7-OH withdrawal last?
Acute withdrawal usually lasts about 3 to 7 days, peaking on days 1 to 3. Sleep problems, anxiety and cravings can continue for weeks.
When does 7-OH withdrawal start?
Usually 6 to 24 hours after the last dose.
What helps with 7-OH withdrawal?
A doctor's evaluation, medication for opioid withdrawal prescribed by a physician, symptom relief for nausea and sleep, fluids, and a structured outpatient program that starts right away.
Can you overdose on 7-OH?
Yes. 7-OH can slow or stop breathing, especially with alcohol, benzodiazepines or other opioids. Call 911 and give naloxone (Narcan) if you suspect an overdose.
Does naloxone work on 7-OH?
Yes. Because 7-OH acts on the opioid receptor, naloxone can reverse a 7-OH overdose, though more than one dose may be needed.
Does Renova Recovery treat 7-OH addiction?
Yes. Renova Recovery in Brick, NJ treats 7-OH and kratom addiction through PHP, IOP and outpatient programs, with individual counseling, relapse prevention and Vivitrol when appropriate.
What are street names for 7-OH?
7-OH is often called 7OH, 7-hydroxy, tabs or shots, and may be labeled as enhanced kratom or kratom extract. A related, stronger compound is sold as pseudo or MP.
What is pseudo kratom?
Pseudo is mitragynine pseudoindoxyl (MP), a compound related to 7-OH and even stronger at the opioid receptor. It became a Schedule I substance on August 26, 2026.
Can you vape 7-OH?
7-OH vapes are sold, but there is almost no safety data on inhaling it. Inhaled or not, it carries the same dependence and overdose risk.
Is 7-OH safe during pregnancy?
No. Babies born to mothers who used kratom regularly have gone through newborn withdrawal. If you're pregnant, talk to your OB before stopping so you can do it safely.
Is 7-OH the same as kratom?
No. Kratom is the plant. 7-OH is one of its alkaloids, making up less than 2 percent of the leaf's alkaloids naturally. 7-OH products concentrate it far beyond natural levels.
Is 7-OH stronger than kratom?
Yes. 7-OH is much stronger at the opioid receptor than mitragynine, kratom's main alkaloid, which is why 7-OH products carry more risk of dependence and overdose.
Does 7-OH show up on a drug test?
Standard 5-panel and 10-panel screens are not designed to detect it, but specialized tests can detect mitragynine and 7-OH, and courts and employers increasingly use them.
What is a safe dose of 7-OH?
There is no established safe dose. Products are unregulated, labels can be inaccurate, and tolerance builds quickly.
Can I quit 7-OH cold turkey?
After heavy daily use, stopping all at once can cause severe withdrawal. Talk to a doctor first so you have a medical plan and support in place.
Does 7-OH cause precipitated withdrawal?
7-OH itself doesn't, but starting buprenorphine (Suboxone) or naltrexone (Vivitrol) while 7-OH is still active can trigger sudden, severe precipitated withdrawal. That's why a prescriber times these medications carefully.
How long after 7-OH can I take Suboxone?
There's no fixed number of hours. Prescribers usually wait until clear withdrawal symptoms have started before the first dose, to avoid precipitated withdrawal. Only start buprenorphine under a prescriber's direction.
How long does 7-OH stay in your system?
It hasn't been well studied. Kratom alkaloids are generally detectable in urine for several days after regular use, and longer after heavy daily use.
Does Renova offer 7-OH detox?
No. Renova is outpatient only. If you need medically managed withdrawal first, we help arrange it and then bring you into our program.
Does insurance cover 7-OH addiction treatment?
Most commercial PPO plans cover outpatient substance use treatment. Renova verifies your benefits on the first call.
Can I keep working during 7-OH treatment?
Often, yes. IOP runs 3 hours a day with morning, afternoon or evening options, and OP meets about 90 minutes, usually in the evening.
How do I help a family member addicted to 7-OH?Title or Question
Learn the signs, keep naloxone at home, talk when they're calm, avoid pushing a cold-turkey quit, and make a confidential first call together.

Sources

U.S. Food and Drug Administration. FDA and Kratom; Hiding in Plain Sight: 7-OH Products. fda.gov
Drug Enforcement Administration. DEA to Temporarily Schedule 7-OH and Related Substances. Press release, July 1, 2026. dea.gov
Federal Register. Schedules of Controlled Substances: Temporary Placement of 7-Hydroxymitragynine Above a Specified Threshold in Schedule I (notice of intent), July 6, 2026.
New Jersey Legislature. S301 (2026–2027 session), Classifies 7-hydroxymitragynine as Schedule I drug; companion A5359.
Management of acute withdrawal from 7-hydroxymitragynine after high-dose chronic use: a case report. Journal of the American Pharmacists Association, 2026.
Buprenorphine for the Management of 7-Hydroxymitragynine (7-OH) Use: A Retrospective Case Series. Journal of Addiction Medicine.
7-Hydroxymitragynine Withdrawal Treated With Buprenorphine-Naloxone. The Primary Care Companion for CNS Disorders.
Michigan Medicine Health Lab. Life-destroying addiction can start at a corner store.
New Jersey Monitor. NJ bill looks to ban kratom products critics call dangerous, March 16, 2026.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR).

7-OH: What It Is, Withdrawal Symptoms and Treatment in New Jersey

7-OH IN 30 SECONDS

What Is 7-OH (7-Hydroxymitragynine)?

7-OH Street Names, Slang and Brand Names

Is 7-OH a New Drug? A Short History

Is 7-OH an Opioid?

How People Use 7-OH

7-OH Tablets

7-OH Capsules

7-OH Gummies

7-OH Shots and Drinks

7-OH Powder

7-OH Pouches

7-OH Vapes

Stacking 7-OH

7-OH Dosage: Why There's No Safe Number

7-OH Effects and Side Effects

Is 7-OH Safe? Overdose Risk and Naloxone

Mixing 7-OH With Alcohol, Benzos or Other Drugs

7-OH, Teens, Children and Pregnancy

Is 7-OH Legal in New Jersey?

Does 7-OH Show Up on a Drug Test?

How long does 7-OH stay in your system?

Is 7-OH Addictive? DSM-5 Criteria

Signs of 7-OH Addiction